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It is possible that isoniazid may decrease the serum levels of ketoconazole after long term treatment.

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Do not take this medicine with any of the following medications -certain medicines used to treat hiv infection or aids that are given in combination with cobicistat – delavirdine – maois like carbex, eldepryl, marplan, nardil, and parnate – nefazodone – oxcarbazepine this medicine may also interact with the following medications – acetaminophen – acetazolamide – barbiturate medicines for inducing sleep or treating seizures, like phenobarbital – certain antibiotics like clarithromycin, erythromycin or troleandomycin – cimetidine – cyclosporine – danazol – dicumarol – doxycycline – female hormones, including estrogens and birth control pills – grapefruit juice – isoniazid, inh – levothyroxine and other thyroid hormones – lithium and other medicines to treat mood problems or psychotic disturbances – loratadine – medicines for angina or high blood pressure – medicines for cancer – medicines for depression or anxiety – medicines for sleep – medicines to treat fungal infections, like fluconazole, itraconazole or ketoconazole – medicines used to treat hiv infection or aids – methadone – niacinamide – praziquantel – propoxyphene – rifampin or rifabutin – seizure or epilepsy medicine – steroid medicines such as prednisone or cortisone – theophylline – tramadol – warfarin.

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Vincristine major isoniazid, inh is a potent inhibitor of cyp3a4, and vincristine is a cyp3a substrate.

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The authors concluded that rifampin may be a reasonable alternative to isoniazid, but that definitive results would require large-scale efficacy trials.

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